SC1000結合了最新的血壓分析技術和經濟的單通道操作模式。測量結果包括脈搏、收縮壓、舒張壓和MAP。該系統可以輕松添加使用無論是小鼠或大鼠的第二個動物平臺。動物固定器經過獨特的設計，確保最大限度的減少未受過訓練的動物的血壓測量的難度。脈沖檢測是通過一個帶有高強度發光二極管的非常靈敏的固態結合的光電二極管探測器來完成的。特別設計的“V”形傳感器組件，有助于固定動物的尾巴。

系統軟件:
Sc1000 COMM Windows應用軟件是特別設計的簡單而有效的嚙齒類動物的血壓測量分析軟件。所有系統功能可以方便的通過標準的Windows的單擊方式來實現?？啥ㄖ瞥跏蓟瘏?，并保存在“Header”菜單下，這樣實驗就可以很容易地進行重復。當進行測量的同時，信號波形也會實時的顯示。

1   單/雙通道操作。
2   同時測量兩個動物。
3 “V型切口”的傳感器組件，有助于固定尾巴。
4   可更換的動物平臺。
5   尾套使用標準的乳膠氣球。
6   所有金屬結構有環氧涂層。

1   單/雙通道操作。
2   同時測量兩個動物。
3 “V型切口”的傳感器組件，有助于固定尾巴。
4   可更換的動物平臺。
5   尾套使用標準的乳膠氣球。
6   所有金屬結構有環氧涂層。

用于無創測量嚙齒動物的血壓，測量結果包括脈搏、收縮壓、舒張壓和MAP。

Loss ofplacental growth factor ameliorates maternal hypertension and preeclampsia inmice.Jacqueline G Parchem, Keizo Kanasaki, +14 authors Raghu KalluriTheJournal of clinical investigation2018

Preeclampsia remains a clinical challenge due to itspoorly understood pathogenesis. A prevailing notion is that increased placentalproduction of soluble fms-like tyrosine kinase-1 (sFlt-1) causes… (More)

RSK2 contributesto myogenic vasoconstriction of resistance arteries by activating smooth musclemyosin and the Na+/H+ exchangerMykhaylo V Artamonov, Swapnil K. Sonkusare, +8 authors Avril V SomlyoScienceSignaling2018

Smooth muscle contraction is triggered whenCa2+/calmodulin-dependent myosin light chain kinase (MLCK) phosphorylates theregulatory light chain of myosin (RLC20). However, blood vesselsfrom… (More)

Alantolactoneplays neuroprotective roles in traumatic brain injury in rats viaanti-inflammatory, anti-oxidative and anti-apoptosis pathways.Xun Wang, Yu‐Long Lan, Jin‐Shan Xing, Xiao-Qiang Lan, Li-tao Wang, Bo ZhangAmericanjournal of translational research2018

Traumatic brain injury (TBI) is a common diseaseassociated with a high rate of morbidity and mortality. Secondary brain injuryfollowing TBI triggers pathological, physiological, and biological… (More)

Adaptation in aChanging World: Evolutionary mechanisms of salt tolerance in a coastalamphibianMolly A Albecker2018

ADAPTATION IN A CHANGING WORLD: EVOLUTIONARYMECHANISMS OF SALT TOLERANCE IN A COASTAL AMPHIBIAN By Molly Ann Albecker July2018 Director of Dissertation: Michael W. McCoy Major Department:Biology… (More)

From Rice Fieldsto Duck Marshes: Sport Hunters and Environmental Change on the South CarolinaCoast, 1890–1950Matthew Allen Lockhart2017

MarineAnimalForests  Sabrina H Rossi, Lorenzo Bramanti, Andrea Gori, Covadonga Orejas  Springer International Publishing 2017

In themarine benthos,megabenthic communities dominated by sessilesus-pension feeders (such assponges, corals, and bivalves) formthree-dimensionalstructures whichprovide architectural… (More)

RadiobiologyandRadiation Hormesis  Dr. Charles L. Sanders  Springer International Publishing  2017

InhibitionofInterleukin 17-A but not Interleukin-17F Signaling Lowers BloodPressureandReduces End-organ Inflammation in Angiotensin II-induced Hypertension.

Mohamed Ayman Saleh, Allison E Norlander, Meena S. Madhur  JACC. Basic to translational science 2016

OBJECTIVESTo characterize the T cell subsetsproducing interleukin 17 (IL-17) isoforms Aand F in hypertensive kidneys andvessels and determine whether inhibition ofIL-17 signaling lowers blood… (More)

InjuryModelsof the Central Nervous System 

Firas H. Kobeissy, C. Edward Dixon, Ronald L. Hayes, Stefania Mondello, Emanuele Scribano, Kevin K-W Wang Methodsin Molecular Biology  2016

Thisnarrative provides a brief history ofexperimental animal model development forthe study of traumatic brain injury.It draws upon a relatively rich history ofearly animal modeling that… (More)

AnimalModelsof Posttraumatic Seizures and Epilepsy.

Alexander V. Glushakov, Olena Y. Glushakova, Sylvain Doré, Paul R. Carney, Ronald L. Hayes  Methods in molecular biology 2016

Posttraumaticepilepsy (PTE) is one of the most commonand devastating complications oftraumatic brain injury (TBI). Currently, theetiopathology and mechanisms ofPTE are poorly understood and as a… (More)

HonoringOurArmed Forces  MATTHEWMCCLINTOCK  2016

and verifyand that we reach out to this last year,when we said as a body that windenergy would not get a production tax creditanymore, and remove it from thetax credit and verify for ourselves… (More)

EffectsofMarine Media on the Growth of Antibiotic Producing Soil Bacteria inMasonboroSound  ALPHABETICALLISTING, Rachel Abele, Sarah P. Lawson  2016

S OFRESEARCH/CREATIVE SCHOLARSHIP ON DIGITAL ORPOSTER DISPLAY -------ALPHABETICALLISTING BY PRIMARY AUTHOR Primary Author:Rachel Abele UndergraduateDepartment/School: Nursing Faculty Supervisor:… (More)

AquaticMicrobialEcology and Biogeochemistry: A Dual Perspective  P M Glibert, Todd M. Kana SpringerInternationalPublishing  2016

Sexdifferencesin NMDA GluN1 plasticity in rostral ventrolateral medulla neuronscontainingcorticotropin-releasing factor type 1 receptor followingslow-pressorangiotensin II hypertension.

Theo A. T. G. Van Kempen, M Dodos, +6 authorsTeresa A Milner  Neuroscience  2015

There areprofound, yet incompletely understood, sexdifferences in the neurogenicregulation of bloodpressure.Both corticotropin signaling and glutamate receptorplasticity, which differbetween… (More)

Renoprotectiveeffectsof combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats  Naoki Kojima, Jan Michael Williams, +4 authorsRichard J. Roman

Physiological reports  2015

This studyexamined whether control of hyperglycemiawith a new SGLT2 inhibitor,luseogliflozin, given alone or in combination with lisinoprilcould prevent thedevelopment of renal injury in… (More)

Slow-pressorangiotensinII hypertension and concomitant dendritic NMDA receptor traffickingin estrogenreceptor beta-containing neurons of the mouse hypothalamicparaventricularnucleus are sex and…  

José Marques-Lopes, Tracey A Van Kempen, Elizabeth Waters  2015

Theincidence of hypertension increases aftermenopause. Similar to humans,“slow-pressor” doses of angiotensin II (AngII)increase bloodpressure in young males, but not in youngfemalemice.… (More)

Preconditioningwithpitavastatin, an HMG-CoA reductase inhibitor, attenuates C-Jun N-terminalkinaseactivation in experimental subarachnoid hemorrhage-induced apoptosis  Chih-Zen Chang, Shu-Chuan Wu, Aij-lie Kwan, Chih-Lung Lin

Acta Neurochirurgica  2015

Accumulatingresults have disclosed that early braininjury (EBI) may play a major role inthe determination of the outcome ofaneurysmal subarachnoid hemorrhage (SAH)patients. This study is of… (More)

Valproicacidattenuates intercellular adhesion molecule-1 and E-selectin through achemokineligand 5 dependent mechanism and subarachnoid hemorrhage inducedvasospasm in arat model

Chih-Zen Chang, Shu-Chuan Wu, Chih-Lung Lin, Aij-lie Kwan  Journal of Inflammation  2015

Up-regulationof regulated upon activation, normalT-cell expressed and secreted(RANTES/CCL5) and adhesion molecules is observedin the serum of animalsfollowing experimental subarachnoid… (More)

4′-O-β-d-glucosyl-5-O-methylvisamminol,anactive ingredient of Saposhnikovia divaricata, attenuates high-mobilitygroupbox 1 and subarachnoid hemorrhage-induced vasospasm in a rat model

Chih-Zen Chang, Shu-Chuan Wu, Aij-lie Kwan, Chih-Lung Lin  Behavioral and Brain Functions 2015

High-mobilitygroup box 1 (HMGB1) was observed to bean important extracellular mediatorinvolved in vascular inflammation associatedwith subarachnoid hemorrhage(SAH). This study is of interest to… (More)

Arctigenin,aPotent Ingredient of Arctium lappa L., Induces Endothelial Nitric OxideSynthaseand Attenuates Subarachnoid Hemorrhage-Induced Vasospasm throughPI3K/AktPathway in a Rat Model

Chih-Zen Chang, Shu-Chuan Wu, Chia-Mao Chang, Chih-Lung Lin, Aij-lie Kwan  BioMed research international 2015

Upregulationof protein kinase B (PKB, also known asAkt) is observed within the cerebralarteries of subarachnoid hemorrhage (SAH) animals.This study is of interest toexamine Arctigenin, a potent… (More)

Renaldepletionof myo-inositol is associated with its increased degradation inanimal models ofmetabolic disease.

H-H Chang, H-N Chao, Claire-Dominique Walker, S C Choong, Anne Phillips, Kerry M. Loomes   American journal of physiology. Renalphysiology  2015

Renaldepletion of myo-inositol (MI) is associatedwith the pathogenesis of diabeticnephropathy in animal models, but theunderlying mechanisms involved areunclear. We hypothesized that MI… (More)

Successinresearch at an undergraduate institution.  Trevor A Day ThePhysiologist  2015

Writing forScientific Meetings October 15-21 (Online)Receive feedback on yourfirst-author abstract while improving your abstractwriting skills. ManuscriptWriting Skills Writing and Reviewing for… (More)

“DopamineTransporterKnockout Mice: What Does This Model Tell Us About the Causes and TreatmentofAttention Deficit Hyperactivity Disorder?”

Matthew I. M. Louder, Henning U. Voss, +4 authorsMark E Hauber 2015

ANewModel of an Arteriovenous Fistula in Chronic Kidney Disease in the 1Mouse:Beneficial Effects of Upregulated Heme Oxygenase-1

Lu Kang, Joseph P Grande, +4 authorsKarl A Nath 2015

MarinePhysiologyDown East: The Story of the Mt. Desert Island Biological Laboratory  David H. Evans Perspectivesin Physiology  2015

IdeologiesofExemplary Masculinity in French and British Adventure Novels 187019001870190018701900  SimonRothon  2015

Theratioof macronutrients, not caloric intake, dictates cardiometabolic health,aging,and longevity in ad libitum-fed mice.

Samantha Solon-Biet, Aisling Mcmahon, +15 authorsStephen J. Simpson  Cell metabolism  2014

Thefundamental questions of what represents amacronutritionally balanced diet andhow this maintains health and longevityremain unanswered. Here, the GeometricFramework, a state-spacenutritional… (More)

Corrigendumto“Magnesium Lithospermate B, an Active Extract of Salvia miltiorrhiza,MediatessGC/cGMP/PKG Translocation in Experimental Vasospasm”

Chih-Zen Chang, Shu-Chuan Wu, Aij-lie Kwan  BioMed research international 2014

[Thiscorrects the article DOI: 10.1155/2014/272101.].

Purpurogallin,aNatural Phenol, Attenuates High-Mobility Group Box 1 in SubarachnoidHemorrhageInduced Vasospasm in a Rat Model

Chih-Zen Chang, Chih-Lung Lin, Shu-Chuan Wu, Aij-lie Kwan  International journal of vascularmedicine  2014

High-mobility groupbox 1 (HMGB1) was shown to be animportant extracellular mediator involved invascular inflammation of animalsfollowing subarachnoid hemorrhage (SAH). Thisstudy is of interest… (More)

Abstractsofthe SICB 2014 Annual Meeting, January 3?7, 2014, Austin, TX.  Harvey Mudd Integrativeand comparativebiology  2014

emily.m.abbott@gmail.comThe effect of musclerelaxation rate on tendon recoil during energy dissipatingtasks Series elasticelements, such as tendons and aponeuroses, can amplifymuscle power,… (More)

RegulationofENaC in mice lacking renal insulin receptors in the collecting duct.

Tengis S Pavlov, Daria V. Ilatovskaya, Vladislav Levchenko, Lijun Li, Carolyn M A Ecelbarger, Alexander Staruschenko  FASEB journal : official publication of the…  2013

Theepithelial sodium channel (ENaC) is one of thecentral effectors involved inregulation of salt and water homeostasis in thekidney. To study mechanisms ofENaC regulation, we generated knockout… (More)

Malecontraceptionvia simultaneous knockout of α1A-adrenoceptors andP2X1-purinoceptors in mice.

C. Whitney White, Yan-Ting Choong, +5 authorsSabatino Ventura   Proceedings of the National Academy ofSciences…2013

Therapeutic targetsfor male contraception areassociated with numerous problems due to their focuson disruptingspermatogenesis or hormonal mechanisms to produce dysfunctionalsperm. Herewe… (More)

Effectsofa new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats.

Naoki Kojima, Jan Michael Williams, Teisuke Takahashi,